@article {7672, title = {Atypical cortical hierarchy in Aβ-positive older adults and its reflection in spontaneous speech}, journal = {Brain Research}, volume = {1830}, year = {2024}, month = {02/2024}, pages = {1-11}, chapter = {1}, abstract = {

Abnormal deposition of A\β amyloid is an early neuropathological marker of Alzheimer\’s disease (AD), arising

long ahead of clinical symptoms. Non-invasive measures of associated early neurofunctional changes, together with easily accessible behavioral readouts of these changes, could be of great clinical benefit. We pursued this aim by investigating large-scale cortical gradients of functional connectivity with functional MRI, which capture the hierarchical integration of cortical functions, together with acoustic-prosodic features from spontaneous

speech, in cognitively unimpaired older adults with and without A\β positivity (total N = 188). We predicted distortions of the cortical hierarchy associated with prosodic changes in the A\β + group. Results confirmed substantially altered cortical hierarchies and less variability in these in the A\β + group, together with an increase

in quantitative prosodic measures, which correlated with gradient variability as well as digit span test scores. Overall, these findings confirm that long before the clinical stage and objective cognitive impairment, increased

risk of cognitive decline as indexed by A\β accumulation is marked by neurofunctional changes in the cortical

hierarchy, which are related to automatically extractable speech patterns and alterations in working memory functions.

}, keywords = {Aβ amyloid, Cognitive decline, Cortical gradient, Dementia, Functional connectivity}, doi = {https://doi.org/10.1016/j.brainres.2024.148806}, url = {https://hal.science/hal-04529221}, author = {Rui He and Jalal Al-Tamimi and Gonzalo Sanchez-Benavides and Guillermo Montana-Valverde and Juan Domingo Gispert and Oriol Grau-Rivera and Marc Suarez-Calvet and Carolina Minguillon and Karine Fauria and Arcadi Navarro and Wolfram Hinzen} } @article {7721, title = {Atypical cortical hierarchy in Aβ-positive older adults and its reflection in spontaneous speech}, journal = {Brain Research}, volume = {1830}, year = {2024}, pages = {148806}, keywords = {Aβ amyloid, Cognitive decline, Cortical gradient, Dementia, Functional connectivity}, doi = {10.1016/j.brainres.2024.148806}, url = {https://hal.science/hal-04529221}, author = {He, Rui and Al-Tamimi, Jalal and S{\'a}nchez-Benavides, Gonzalo and Monta{\~n}a-Valverde, Guillermo and Domingo Gispert, Juan and Grau-Rivera, Oriol and Su{\'a}rez-Calvet, Marc and Minguillon, Carolina and Fauria, Karine and Navarro, Arcadi and Hinzen, Wolfram} }